Augmentin is a medicine that contains Amoxicillin and Clavulanate (clavulanic acid). Amoxicillin acts by inhibiting penicillin-binding proteins (PBPs) that play an important role in the synthesis of bacterial cell walls. By blocking the bacterial cell wall synthesis, Amoxicillin exhibits a bactericidal effect (kills bacteria). Unfortunately, over time, bacteria developed a mechanism to fight this active ingredient by initiating the formation of an enzyme called beta-lactamase. Beta-lactamase degrades all antibiotics that have a beta-lactam structure. The sole use of Augmentin has therefore become ineffective in the treatment of certain Amoxicillin-resistant infections. That’s why Amoxicillin is often combined with Clavulanate, which has the role of degrading beta-lactamase produced by bacteria, thus preventing the degradation of Amoxicillin.
Augmentin is used to treat the following infections in children and adults:
- Bacterial infections of the upper respiratory tract (tonsillitis, pharyngitis, and sinusitis).
- Middle-ear bacterial infections (otitis media).
- Bacterial infections of the lower respiratory tract (bronchitis and pneumonia).
- Bacterial infections of the upper urinary tract occurring in the kidney (pyelonephritis).
- Bacterial infections of the bladder (cystitis).
- Bacterial bone and joint infections.
- Bacterial infections of the skin and soft tissue.
Augmentin has proven to be effective in treating infections caused by the following bacteria:
- Staphylococcus aureus
- Staphylococcus saprophyticus
- Staphylococcus epidermidis
- Escherichia coli
- Klebsiella species
- Fusobacterium species
- Enterobacter species
- Moraxella catarrhalis
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Proteus mirabilis
- Neisseria gonorrhoeae
It is always recommended to make an antibiogram before starting Augmentin. In this way, the doctor will determine whether bacteria that caused the infection are sensitive to this drug.
www.meds4sure.com/buy-augmentin-amoxicillin-clavulanate-online.html exists in various pharmaceutical forms, including:
- Oral suspension (syrup), 125mg/5ml.
- Oral suspension (syrup), 200mg/5ml.
- Oral suspension (syrup), 250mg/5ml.
- Oral suspension (syrup), 400mg/5 ml.
- Tablets, 375mg (containing 250mg of Amoxicillin and 125mg of Clavulanate).
- Tablets, 625mg (containing 500mg of Amoxicillin and 125mg of Clavulanate).
- Tablets, 1000mg (containing 875mg of Amoxicillin and 125mg of Clavulanate).
The dose depends primarily on the severity of the infection and the age of the patient.
The recommended dose for infants under 3 months of age is 30 mg/kg daily divided into two doses. For example, if your baby weighs 4 kg, then the daily dosage will be 4 x 30 = 120mg daily (divided into two doses: 60mg twice daily). This means you should give 2.5ml of the Augmentin 125mg/5ml syrup twice a day. The Augmentin 125 mg/5 ml syrup is suitable for infants younger than 3 months and it is not recommended to use syrups that have a higher concentration of Amoxicillin because infants below 3 months of age do not have a sufficiently developed kidney function to be able to excrete whole amount of drug.
The recommended dose for children older than 3 months and children who weigh up to 40 kg in the treatment of otitis media, sinusitis, bronchitis, pneumonia, and other serious infections is 22.5mg/kg twice a day. The recommended dosage for children older than 3 months and children who weigh up to 40 kg in the treatment of less serious infections (tonsillitis, mild forms of pharyngitis, etc.) is 12.5mg/kg twice a day.
The recommended dose for patients who weigh more than 40 kg in the treatment of severe infections is 1000mg of Augmentin twice a day, while the dosage in the treatment of less severe infections is 625mg twice a day.
Important to Know
Augmentin is more likely to cause side effects (especially diarrhea) if it is administered three times a day than when administered twice a day, although the total daily dose is less when administered three times a day. It has also been proven that taking this drug at the start of the meal significantly reduces the risk of digestive side effects, which are a relatively common.
Animal studies have shown that Augmentin is safe for use during pregnancy. It has also been proven that this medicine does not cause congenital malformations in pregnant women. However, one study has shown that the drug can cause necrotizing enterocolitis in newborns whose mothers have taken Augmentin during pregnancy. Given that necrotizing enterocolitis can endanger the life of newborns, a careful estimate of the benefit / risk is required prior starting this medicine during pregnancy.
Both active substances are excreted in breast milk and can cause fungal infections of the mouth mucous membrane or diarrhea in infants. If an adverse event occurs in infants, breastfeeding should be discontinued during the therapy.
Augmentin should not be used in patients who are allergic to any beta-lactam antibiotic (Cephalosporins and Penicillin). Allergic reactions, such as itching, urticaria, erythema multiforme, vasculitis, exfoliative dermatitis, muscle pain, joint pain, and anaphylactic shock, can occur. If any symptoms of an allergy occur, you must contact your doctor immediately.
Augmentin can cause liver damage, which is usually mild and reversible. However, cases of fatal outcomes due to acute liver damage (occurring in less than 0.00025% of patients) have been reported. If you notice signs of liver damage, such as jaundice and pain in the upper right stomach, you should contact your physician immediately. Keep in mind that liver damage can occur even a few weeks after discontinuation of the therapy.
The presence of crystals and blood in the urine has been also reported as a possible adverse effect of Augmentin. If you notice crystals in the urine or changed urine color, you should contact your doctor immediately, as this may be a sign of kidney damage.
Decrease in the number of red blood cells (anemia), white blood cells (leukopenia), and blood platelets (thrombocytopenia) have also been reported as a rare adverse effect of the drug. If you notice malaise, tingling of the fingers, pale skin (signs of anemia), bruising (sign of thrombocytopenia), or weakened immunity (leukopenia), you should contact your doctor.
Augmentin can cause the following side effects:
- Fungal infections in the mouth
- Allergic reactions
- Food digestion disorders
- Liver damage
- Pseudomembranous colitis
Contact your doctor if you notice any side effects.